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USP21 and RNF185
Data Source:
BioGRID
(two hybrid)
USP21
RNF185
Description
ubiquitin specific peptidase 21
ring finger protein 185
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Protein Binding
Ubiquitin Binding
Ubiquitin-like Protein Conjugating Enzyme Binding
Protein-containing Complex Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Ubiquitin-dependent ERAD Pathway
ERAD Pathway
Protein Autoubiquitination
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Positive Regulation Of ERAD Pathway
Endoplasmic Reticulum Mannose Trimming
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Fish- and plant-related diet (
32066663
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Waist circumference (
28552196
)
White blood cell count (
32888494
)
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
32 interacting genes:
APP
CGAS
CMTM5
CYB561A3
DVL2
FAM241B
MALL
MS4A13
MTNR1B
MYADML2
NIPAL4
RNF5
TMBIM6
TMEM147
TMEM19
TMEM86A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2V1
UBE2W
USP21
YIPF2
YIPF4
YIPF6
Entrez ID
27005
91445
HPRD ID
05291
08790
Ensembl ID
ENSG00000143258
ENSG00000138942
Uniprot IDs
Q9UK80
A0A024R1F5
A0A024R1H4
Q96GF1
PDB IDs
2Y5B
3I3T
3MTN
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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