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USP21 and USP15
Data Source:
BioGRID
(enzymatic study, enzymatic study)
USP21
USP15
Description
ubiquitin specific peptidase 21
ubiquitin specific peptidase 15
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Modification-dependent Histone Binding
Lys48-specific Deubiquitinase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
BMP Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathway-restricted SMAD Protein Phosphorylation
Protein K48-linked Deubiquitination
Positive Regulation Of RIG-I Signaling Pathway
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
55 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
DDX58
FHL1
GEMIN4
GOLGA2
GOLGA6A
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RNF126
RNF144B
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBE2S
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
Entrez ID
27005
9958
HPRD ID
05291
05293
Ensembl ID
ENSG00000143258
ENSG00000135655
Uniprot IDs
Q9UK80
Q9Y4E8
PDB IDs
2Y5B
3I3T
3MTN
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
Enriched GO Terms of Interacting Partners
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