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USP21 and EFEMP2
Data Source:
BioGRID
(two hybrid)
USP21
EFEMP2
Description
ubiquitin specific peptidase 21
EGF containing fibulin extracellular matrix protein 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
27005
30008
HPRD ID
05291
05221
Ensembl ID
ENSG00000143258
ENSG00000172638
Uniprot IDs
Q9UK80
A0A024R5G1
O95967
Q9H3D5
PDB IDs
2Y5B
3I3T
3MTN
2KL7
Enriched GO Terms of Interacting Partners
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