USP21 and STAMBP

Data Source:
BioGRID (enzymatic study)

		USP21	STAMBP
Description		ubiquitin specific peptidase 21	STAM binding protein
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Metalloprotease DUBs
Drugs
Diseases
GWAS			Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)
Interacting Genes		59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	45 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28
Entrez ID		27005	10617
HPRD ID		05291	05877
Ensembl ID		ENSG00000143258	ENSG00000124356
Uniprot IDs		Q9UK80	A0A140VK54 O95630
PDB IDs		2Y5B 3I3T 3MTN	2XZE 3RZU 3RZV 5IXF
Enriched GO Terms of Interacting Partners?
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