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H2AC18 and RCC1
Data Source:
HPRD
(in vitro)
H2AC18
RCC1
Description
H2A clustered histone 18
regulator of chromosome condensation 1
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Exosome
Chromatin
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Membrane
Protein-containing Complex
Molecular Function
Molecular_function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Small GTPase Binding
Nucleosome Binding
Nucleosomal DNA Binding
Histone Binding
Sulfate Binding
Protein Heterodimerization Activity
Biological Process
Chromatin Silencing
Biological_process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Spindle Organization
Chromosome Segregation
Regulation Of Mitotic Nuclear Division
Viral Process
Ran Protein Signal Transduction
Regulation Of Catalytic Activity
Spindle Assembly
Cell Division
Regulation Of Mitotic Spindle Assembly
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Rev-mediated nuclear export of HIV RNA
Nuclear import of Rev protein
Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS
Night sleep phenotypes (
27126917
)
Systolic blood pressure (
30578418
)
Interacting Genes
20 interacting genes:
APP
BAP1
BMI1
DNAJC2
H2BC15
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF168
RNF169
RNF2
RNF20
TBL1X
UBC
UBE2H
USP16
USP21
50 interacting genes:
ACTB
APLP1
BAG6
CCT7
CDK1
CDK2AP2
CHGB
CHKA
CSAD
CSNK1A1
DDAH2
DYNC1I1
ERCC6
FAF1
FBXO7
FLAD1
GNB2
H2AC18
H2AC20
H2BC21
H3C1
HADHB
HMGA1
HOXD8
KMT2B
KPNA3
KPNA4
LRIF1
NGFR
NTMT1
NUDT21
NUP98
PDHB
PKM
PTMA
RAN
RANBP1
RANBP3
RPA1
SDF4
SPRED1
SUMO2
TLE1
TRMT2A
TUBB3
UNC119
USP4
WIZ
XPO1
ZNF135
Entrez ID
8337
1104
HPRD ID
08851
01559
Ensembl ID
ENSG00000203812
ENSG00000180198
Uniprot IDs
Q6FI13
A0A0S2Z3I4
A0A0S2Z404
P18754
Q5T081
PDB IDs
6SE6
6SEE
6SEF
6SEG
6Y5D
1A12
1I2M
5E1B
5E1D
5E1M
5E1O
5E2A
5E2B
5TBK
6DUB
Enriched GO Terms of Interacting Partners
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