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H2AC18 and PRMT6
Data Source:
BioGRID
(enzymatic study)
H2AC18
PRMT6
Description
H2A clustered histone 18
protein arginine methyltransferase 6
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Exosome
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
Molecular_function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Chromatin Binding
Protein Binding
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Protein-arginine Omega-N Monomethyltransferase Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity
Histone Binding
Histone Methyltransferase Activity (H4-R3 Specific)
Histone Methyltransferase Activity (H3-R2 Specific)
Histone Methyltransferase Activity (H2A-R3 Specific)
Biological Process
Chromatin Silencing
Biological_process
Negative Regulation Of Transcription By RNA Polymerase II
Base-excision Repair
Regulation Of Mitochondrion Organization
Viral Process
Histone Methylation
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Negative Regulation Of Histone Deacetylation
Histone H3-R2 Methylation
Histone H4-R3 Methylation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Histone H3-K4 Methylation
Cellular Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Blood pressure measurement (low sodium intervention) (
24165912
)
Intelligence (
22449649
)
Low density lipoprotein cholesterol levels (
32154731
)
Non-obstructive azoospermia (
22197933
)
Obesity (early onset extreme) (
23563609
)
Refractive error (
32231278
)
Response to SSRI in MDD or openness (
29559929
)
Restless legs syndrome (
29029846
)
Sex hormone-binding globulin levels (
22829776
)
Waist circumference (
28552196
)
Weight (
28552196
)
Interacting Genes
20 interacting genes:
APP
BAP1
BMI1
DNAJC2
H2BC15
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF168
RNF169
RNF2
RNF20
TBL1X
UBC
UBE2H
USP16
USP21
90 interacting genes:
AK8
AP1G2
ASB3
AUNIP
BCAT1
BLZF1
BMP3
C8orf74
CDCA4
CETN2
DCAF16
DNAJA3
DNALI1
DXO
FBL
FIP1L1
FKBP7
FYCO1
FYN
GBE1
GPS2
GRHL3
GSTCD
GTPBP2
H2AC18
H2BC21
H3-5
H3C14
H3C15
H4-16
H4C6
HESX1
HMGA1
HMGA2
HNRNPH2
HOXA1
HOXA5
HOXC4
ID2
KIAA0408
KIF9
KLHL20
LDHAL6B
LENG8
LINC02875
LOXL4
MALT1
MED28
METTL27
MLC1
MNDA
MTF2
NEFL
NOSTRIN
NR1D2
OAS1
OPA3
PABPC1
PCGF5
PELO
PEX7
PSMD11
PYCR3
PYGO1
RAC1
RAD17
RASSF2
SERGEF
SLU7
SMAD9
SMARCD1
SNF8
SPATA22
SPIN1
SPSB1
SRGAP3
SSX2IP
STARD10
SUV39H1
TDO2
TEX35
THEMIS
TMED5
TRIB2
TSC1
UBXN10
WDFY3
ZNF436
ZNF557
ZSCAN9
Entrez ID
8337
55170
HPRD ID
08851
10505
Ensembl ID
ENSG00000203812
ENSG00000198890
Uniprot IDs
Q6FI13
Q96LA8
PDB IDs
6SE6
6SEE
6SEF
6SEG
6Y5D
4HC4
4QPP
4QQK
4Y2H
4Y30
5E8R
5EGS
5HZM
5WCF
6P7I
6W6D
6WAD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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