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USP21 and USP14
Data Source:
BioGRID
(enzymatic study)
USP21
USP14
Description
ubiquitin specific peptidase 21
ubiquitin specific peptidase 14
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Proteasome Complex
Nucleus
Cytosol
Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Proteasome Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Innate Immune Response
Regulation Of Chemotaxis
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Ub-specific processing proteases
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
11 interacting genes:
COPS5
CXCR4
FANCC
SEM1
SPAG5-AS1
TRIM11
UBC
USP15
USP21
USP28
XRCC6
Entrez ID
27005
9097
HPRD ID
05291
06279
Ensembl ID
ENSG00000143258
ENSG00000101557
Uniprot IDs
Q9UK80
P54578
PDB IDs
2Y5B
3I3T
3MTN
2AYN
2AYO
5GJQ
6IIK
6IIL
6IIM
6IIN
6LVS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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