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USP21 and USP7
Data Source:
BioGRID
(enzymatic study)
USP21
USP7
Description
ubiquitin specific peptidase 21
ubiquitin specific peptidase 7
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Chromosome
Cytosol
Nuclear Body
PML Body
Protein-containing Complex
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
P53 Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
Ubiquitinyl Hydrolase Activity
Lys48-specific Deubiquitinase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Regulation Of Gluconeogenesis
Transcription-coupled Nucleotide-excision Repair
Ubiquitin-dependent Protein Catabolic Process
Multicellular Organism Development
Maintenance Of DNA Methylation
Viral Process
Protein Ubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Protein Stability
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Regulation Of Circadian Rhythm
Rhythmic Process
Protein Stabilization
Regulation Of DNA-binding Transcription Factor Activity
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Positive Regulation Of DNA Demethylation
Regulation Of Telomere Capping
Regulation Of Retrograde Transport, Endosome To Golgi
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Ub-specific processing proteases
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Regulation of PTEN localization
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
103 interacting genes:
ABRAXAS2
ACD
ANKS1A
ANXA1
ARNT2
ATXN1
AXIN1
BCOR
BEND5
CBX8
CLSPN
CREB3L3
CRY1
CSNK2A1
DAXX
DCTPP1
DNAJA3
DNMT3A
ERCC6
EWSR1
FOXN2
GATA1
H2AC20
H2BU1
HECW1
HERPUD1
HIF1A
HTRA2
HUWE1
IFNAR1
KAT5
KDM1A
KLHL8
LINC02582
MAGEE1
MAL
MARCHF7
MCMBP
MDM2
MDM4
MYC
MYD88
NECAB2
NOTCH1
OTUD4
PCGF2
PEG3
PEPD
PHF8
PHLDB2
PICK1
PLA2G2A
PLEKHO1
PLK1
PPARG
PPL
PSMD4
PTEN
RAD18
RADIL
RARA
RB1
RBCK1
RELA
RFFL
RNF168
RNF220
SIRT7
SMAD3
SNCA
SUMO2
SYVN1
TANK
TBCB
TFIP11
TMPO
TP53
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM22
TRIM31
TRIM54
TRIM55
TRIM63
TRIM8
TRO
UBA52
UBC
UBE2D3
UBE2E1
UBE2S
USP21
USP28
VCP
WWP2
XPC
ZMYND8
ZNF423
ZNF76
Entrez ID
27005
7874
HPRD ID
05291
03950
Ensembl ID
ENSG00000143258
ENSG00000187555
Uniprot IDs
Q9UK80
B7Z855
B7ZAX6
Q6U8A4
Q93009
PDB IDs
2Y5B
3I3T
3MTN
1NB8
1NBF
1YY6
1YZE
2F1W
2F1X
2F1Y
2F1Z
2FOJ
2FOO
2FOP
2KVR
2XXN
2YLM
3MQR
3MQS
4JJQ
4KG9
4M5W
4M5X
4PYZ
4WPH
4WPI
4YOC
4YSI
4Z96
4Z97
5C56
5C6D
5FWI
5GG4
5J7T
5JTJ
5JTV
5KYB
5KYC
5KYD
5KYE
5KYF
5N9R
5N9T
5NGE
5NGF
5UQV
5UQX
5VS6
5VSB
5VSK
5WHC
6F5H
6P5L
6VN2
6VN3
6VN4
6VN5
6VN6
7CM2
Enriched GO Terms of Interacting Partners
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