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USP21 and UBE2S
Data Source:
BioGRID
(enzymatic study)
USP21
UBE2S
Description
ubiquitin specific peptidase 21
ubiquitin conjugating enzyme E2 S
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Protein Polyubiquitination
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
Protein K29-linked Ubiquitination
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
42 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC2
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CCNB1
CDC16
CDC20
CDC23
CDC27
CTNNB1
CYLD
FBXO5
FZR1
GMNN
HERC1
LINC00839
MDM2
OTUB1
OTUD7B
PRKN
PTEN
RBCK1
RNF7
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP15
USP2
USP21
USP5
USP7
VHL
ZRANB1
Entrez ID
27005
27338
HPRD ID
05291
15603
Ensembl ID
ENSG00000143258
ENSG00000108106
Uniprot IDs
Q9UK80
Q16763
PDB IDs
2Y5B
3I3T
3MTN
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
Enriched GO Terms of Interacting Partners
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