H2AC18 and NOC2L

Data Source:
BioGRID (pull down)

		H2AC18	NOC2L
Description		H2A clustered histone 18	NOC2 like nucleolar associated transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Noc1p-Noc2p Complex Noc2p-Noc3p Complex
	Molecular Function	Molecular_function DNA Binding Protein Binding Protein Heterodimerization Activity	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Nucleosome Binding Histone Binding Repressing Transcription Factor Binding
	Biological Process	Chromatin Silencing Biological_process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Chromatin Assembly Cellular Response To UV Negative Regulation Of Histone Acetylation Ribosomal Large Subunit Biogenesis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS			California verbal learning test score ( 31596458) Pancreatic cancer ( 29422604)
Interacting Genes		20 interacting genes: APP BAP1 BMI1 DNAJC2 H2BC15 IL33 MSL2 NOC2L PARP1 PRMT6 RCC1 RNF168 RNF169 RNF2 RNF20 TBL1X UBC UBE2H USP16 USP21	10 interacting genes: APP ATN1 ATXN7 H2AC18 H2BP1 H3-4 H4-16 LRIF1 PPP1CA RBFOX1
Entrez ID		8337	26155
HPRD ID		08851	13166
Ensembl ID		ENSG00000203812	ENSG00000188976
Uniprot IDs		Q6FI13	Q9Y3T9
PDB IDs		6SE6 6SEE 6SEF 6SEG 6Y5D
Enriched GO Terms of Interacting Partners?
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