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H2AC18 and UBE2H
Data Source:
HPRD
(in vitro)
H2AC18
UBE2H
Description
H2A clustered histone 18
ubiquitin conjugating enzyme E2 H
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Exosome
Nucleus
Cytosol
Molecular Function
Molecular_function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Chromatin Silencing
Biological_process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
31451708
)
Lymphocyte counts (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Response to antidepressants and depression (
27622933
)
White blood cell count (
32888494
)
Interacting Genes
20 interacting genes:
APP
BAP1
BMI1
DNAJC2
H2BC15
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF168
RNF169
RNF2
RNF20
TBL1X
UBC
UBE2H
USP16
USP21
68 interacting genes:
BRAP
BYSL
CBLC
CD99
CDK2
DTX3
DTX3L
DZIP3
EPS15
GOLGA2
H2AC18
HBP1
HDAC6
JADE1
LNX2
LRSAM1
MAEA
MARCHF1
MARCHF10
MARCHF2
MARCHF4
MARCHF8
MKRN3
NEURL1
NHLRC1
POLL
POLM
PRKN
PSME3
RAG1
RELA
RNF10
RNF103
RNF113B
RNF114
RNF128
RNF133
RNF139
RNF144A
RNF146
RNF166
RNF185
RNF186
RNF2
RNF34
RNF38
RNF4
RNF6
STAM2
TLE5
TRAIP
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM36
TRIM37
TRIM5
TRIM56
TRIM69
TRIM72
UBA1
UBASH3B
UBOX5
UBR2
UBR3
Entrez ID
8337
7328
HPRD ID
08851
03052
Ensembl ID
ENSG00000203812
ENSG00000186591
Uniprot IDs
Q6FI13
A0A3B3IU20
A4D1L5
P62256
PDB IDs
6SE6
6SEE
6SEF
6SEG
6Y5D
2Z5D
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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