LAPTM5 and ANKRD13A

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAPTM5	ANKRD13A
Description		lysosomal protein transmembrane 5	ankyrin repeat domain 13A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytoplasm Late Endosome Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Binding Protein Sequestering Activity	Ubiquitin-dependent Protein Binding
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of MAPK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Golgi To Lysosome Transport Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Negative Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Endosome
Pathways
Drugs
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Metabolite levels (MHPG) ( 23319000) Systolic blood pressure ( 30578418)
Interacting Genes		39 interacting genes: AIG1 ANKRD13A C4orf3 CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	11 interacting genes: FBXO25 GRB2 LAPTM5 MFHAS1 QDPR RNF11 SMAD5 SMURF1 UBC VCP WBP2
Entrez ID		7805	88455
HPRD ID		03280	12458
Ensembl ID		ENSG00000162511	ENSG00000076513
Uniprot IDs		Q13571 Q5TBB8	Q3ZTS7 Q8IZ07 Q9Y5A3
PDB IDs
Enriched GO Terms of Interacting Partners?
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