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STAMBP and SNCA
Data Source:
BioGRID
(enzymatic study)
STAMBP
SNCA
Description
STAM binding protein
synuclein alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Membrane
Cleavage Furrow
Extracellular Exosome
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Cell Cortex
Actin Cytoskeleton
Membrane
Inclusion Body
Axon
Growth Cone
Platelet Alpha Granule Membrane
Protein-containing Complex
Neuronal Cell Body
Axon Terminus
Perinuclear Region Of Cytoplasm
Supramolecular Fiber
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metallopeptidase Activity
Protein Domain Specific Binding
Metal Ion Binding
Lys63-specific Deubiquitinase Activity
Isopeptidase Activity
SNARE Binding
Magnesium Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Actin Binding
Protein Kinase Inhibitor Activity
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
Kinesin Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Tau Protein Binding
Phosphoprotein Binding
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Cuprous Ion Binding
Biological Process
Mitotic Cytokinesis
Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Ras Protein Signal Transduction
Protein K63-linked Deubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Chemical Synaptic Transmission
Response To Iron(II) Ion
Regulation Of Phospholipase Activity
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Negative Regulation Of Transporter Activity
Response To Lipopolysaccharide
Negative Regulation Of Monooxygenase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Interferon-gamma
Cellular Response To Oxidative Stress
Negative Regulation Of Histone Acetylation
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Dopamine Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Synaptic Vesicle Endocytosis
Positive Regulation Of Inflammatory Response
Synapse Organization
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Supramolecular Fiber Organization
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Glutathione Peroxidase Activity
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Pathways
Metalloprotease DUBs
Amyloid fiber formation
Drugs
Resveratrol
Copper
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Anti-saccade response (
29064472
)
Blood metabolite levels (
26401656
)
Serum metabolite levels (
23093944
)
Blood protein levels (
30072576
29875488
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
22451204
20711177
21084426
21292315
19915575
19915576
25064009
32201043
31660654
27182965
28892059
22438815
28011712
20070850
21044948
24511991
21738487
32310270
)
Parkinson's disease (age of onset) (
31660654
30957308
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Interacting Genes
45 interacting genes:
ALAS1
AMN
APOBEC3A
BMPR1B
CASR
CHMP1A
CHMP1B
CHMP2A
CHMP3
CHMP4A
CHMP4B
CHMP4C
CHMP5
CLTC
CTNNBL1
CYP2C9
EPS15
GRAP2
GRB2
IL1RL2
ITGA5
MAP2K5
MAP3K2
NLRP3
NLRP7
NTPCR
PJA1
RECQL5
RNF11
SMAD2
SMAD6
SMAD7
SNCA
SPG7
STAM
STAM2
TNFRSF1A
TP53
TRAF6
TRIP13
UACA
UBC
UBE2S
USP21
USP28
126 interacting genes:
A1BG
ACTA1
ADAP2
ADRB2
AKT1
AMBRA1
ANXA6
APLP1
APP
ARHGAP15
ARPP19
ARSA
BAD
BAG5
BCL2L1
BDH2
CALM1
CAV1
CDC42EP2
CDC42EP3
CDC42SE1
CDK4
CHRM5
COL25A1
CRYAB
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CTNND1
CTSD
CYCS
DMTN
DNAJC5
DOCK7
DYRK1A
EEF1A1
EGFR
EIF3G
ELK1
ENC1
ENSA
FBXL5
FGR
FKBP4
FYN
GABARAPL1
GAPDH
GBA
GRK1
GRK2
GRK5
GRK6
GSK3B
H1-1
H1-2
HSD17B4
HSP90AA1
HSPB2
HSPB6
HSPB8
KIAA1191
KLC1
KLK6
LYN
MAP1B
MAPK1
MAPK8IP1
MAPT
MEF2D
MT-CO1
MT-CO3
NEDD4
NEDD4L
PAK3
PARK7
PDE4DIP
PDIA2
PELP1
PFDN2
PLCB2
PLD1
PLK1
PLK2
PLK3
PPP3CA
PRDX1
PREP
PRKCE
PRKN
PTK2B
RABAC1
RNF10
SAP30BP
SDF4
SEPTIN4
SIAH2
SLC6A3
SMURF2
SNCAIP
SNCB
SPTBN1
SQSTM1
SRC
SRI
STAMBP
SYK
SYN1
TGM1
TH
TOR1A
TPPP
TUBA1A
UBB
UBC
UBE2D2
UBE2W
USP2
USP47
USP7
USP8
YOD1
YWHAB
YWHAE
YWHAH
ZRANB1
Entrez ID
10617
6622
HPRD ID
05877
01227
Ensembl ID
ENSG00000124356
ENSG00000145335
Uniprot IDs
A0A140VK54
O95630
H6UYS5
P37840
PDB IDs
2XZE
3RZU
3RZV
5IXF
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6FLT
6H6B
6I42
6L1T
6L1U
6L4S
6LRQ
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
6SST
6SSX
6UFR
6XYO
6XYP
6XYQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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