STAMBP and NLRP7

Data Source:
BioGRID (enzymatic study)

		STAMBP	NLRP7
Description		STAM binding protein	NLR family pyrin domain containing 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Cellular_component
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	ATP Binding Aspartic-type Endopeptidase Inhibitor Activity Interleukin-1 Binding Caspase Binding
	Biological Process	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Aspartic-type Peptidase Activity
Pathways		Metalloprotease DUBs
Drugs
Diseases			Recurrent hydatidiform moles (RHM); Familial biparental hydatidiform
GWAS		Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)	Inflammatory bowel disease ( 23128233)
Interacting Genes		45 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28	2 interacting genes: FAF1 STAMBP
Entrez ID		10617	199713
HPRD ID		05877	10112
Ensembl ID		ENSG00000124356	ENSG00000167634
Uniprot IDs		A0A140VK54 O95630	Q8WX94
PDB IDs		2XZE 3RZU 3RZV 5IXF	2KM6
Enriched GO Terms of Interacting Partners?
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