STAMBP and IL1RL2

Data Source:
BioGRID (enzymatic study)

		STAMBP	IL1RL2
Description		STAM binding protein	interleukin 1 receptor like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination	Inflammatory Response Cellular Defense Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of T Cell Differentiation Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Metalloprotease DUBs	Interleukin-38 signaling Interleukin-36 pathway
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31959851 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		45 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28	4 interacting genes: IL18 OTUB1 STAMBP USP2
Entrez ID		10617	8808
HPRD ID		05877	05150
Ensembl ID		ENSG00000124356	ENSG00000115598
Uniprot IDs		A0A140VK54 O95630	Q9HB29
PDB IDs		2XZE 3RZU 3RZV 5IXF	6U6U
Enriched GO Terms of Interacting Partners?
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