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TNK2 and SIAH1
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
TNK2
SIAH1
Description
tyrosine kinase non receptor 2
siah E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Grb2-EGFR Complex
Cytoophidium
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Molecular Function
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Endocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Small GTPase Mediated Signal Transduction
Phosphorylation
Cell Differentiation
Negative Regulation Of GTPase Activity
Innate Immune Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-dependent Endocytosis
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
ATP
Debromohymenialdisine
Entrectinib
Fostamatinib
Diseases
GWAS
Asthma (
31959851
)
Bronchopulmonary dysplasia (
23897914
)
Low density lipoprotein cholesterol levels (
30498476
)
Total cholesterol levels (
30498476
)
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Interacting Genes
49 interacting genes:
AKT1
AQP1
AR
ARSL
BAG3
CDC42
CLTC
CSPG4
CTTN
CYSRT1
DPH2
EGFR
FGFR1
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NLA
NPHP1
PDGFRB
PIK3R3
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SH2D1B
SIAH1
SMURF1
SNX9
SOCS4
SRC
SRSF5
VTI1B
WAS
WWOX
WWP2
YES1
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
Entrez ID
10188
6477
HPRD ID
06104
03736
Ensembl ID
ENSG00000061938
ENSG00000196470
Uniprot IDs
A0A499FJ16
A0A5F9ZGX5
A0A5F9ZHJ2
B3KXJ4
C9J1X3
Q07912
Q8IUQ4
PDB IDs
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
5ZXB
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
Enriched GO Terms of Interacting Partners
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