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SIAH1 and HIPK2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology)
SIAH1
HIPK2
Description
siah E3 ubiquitin protein ligase 1
homeodomain interacting protein kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
SMAD Binding
Virion Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Retina Layer Formation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Modulation By Virus Of Host Process
Neuron Differentiation
Erythrocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SUMOylation of transcription cofactors
Physiological factors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of MECP2 expression and activity
Drugs
Fostamatinib
Diseases
GWAS
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis (
26980576
)
Systolic blood pressure (
28135244
)
Interacting Genes
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
52 interacting genes:
AATF
ABL1
BTRC
CBX3
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DDX39A
DDX39B
FBXW7
H2BC21
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
PARP1
PAX6
PML
PTCH1
RANBP9
RUNX1
SENP1
SIAH1
SIAH2
SIRT1
SKI
SMAD1
SMAD2
SMAD3
SP100
SUMO1
SUMO2
SUMO3
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
Entrez ID
6477
28996
HPRD ID
03736
06039
Ensembl ID
ENSG00000196470
ENSG00000064393
Uniprot IDs
Q8IUQ4
Q9H2X6
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
6P5S
Enriched GO Terms of Interacting Partners
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