TNK2 and MCF2

Data Source:
HPRD (in vivo, in vitro)

		TNK2	MCF2
Description		tyrosine kinase non receptor 2	MCF.2 cell line derived transforming sequence
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium	Cytosol Cytoskeleton Membrane
	Molecular Function	Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Differentiation Negative Regulation Of GTPase Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis	G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs		ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS		Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)	Metabolite levels ( 23823483)
Interacting Genes		49 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	8 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG STUB1 TNK2
Entrez ID		10188	4168
HPRD ID		06104	02406
Ensembl ID		ENSG00000061938	ENSG00000101977
Uniprot IDs		A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912	B2R9S6 P10911
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB
Enriched GO Terms of Interacting Partners?
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