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SIAH1 and ZYX
Data Source:
BioGRID
(pull down)
SIAH1
ZYX
Description
siah E3 ubiquitin protein ligase 1
zyxin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Phagocytic Vesicle
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Binding
Protein Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Cell-matrix Adhesion
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Cell-cell Signaling
Viral Process
Stress Fiber Assembly
Regulation Of Inflammatory Response
Cellular Response To Interferon-gamma
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Artenimol
Diseases
GWAS
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
28240269
)
Monocyte percentage of white cells (
32888494
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
35 interacting genes:
ACTN1
ATXN1
BSPRY
CASS4
ENAH
EVL
HIPK3
IMP3
LAP3
LASP1
LATS1
LIN7A
NEBL
NEDD9
NME5
OPRM1
PDLIM5
PHF21A
QRICH1
RABEPK
RGS2
RPH3AL
RTN4IP1
SIAH1
SREBF2
TES
TUFT1
VASP
VAV1
VAV3
WNK1
YPEL3
ZHX1
ZNF384
ZNF512B
Entrez ID
6477
7791
HPRD ID
03736
03592
Ensembl ID
ENSG00000196470
ENSG00000159840
Uniprot IDs
Q8IUQ4
Q15942
Q96AF9
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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