TNK2 and KCNA5

Data Source:
BioGRID (pull down, enzymatic study)

		TNK2	KCNA5
Description		tyrosine kinase non receptor 2	potassium voltage-gated channel subfamily A member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Integral Component Of Membrane Z Disc Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Signaling Receptor Binding Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Differentiation Negative Regulation Of GTPase Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis	Response To Hypoxia Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Response To Organic Substance Regulation Of Vasoconstriction Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Potassium Ion Transport Regulation Of Insulin Secretion Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation
Pathways			Voltage gated Potassium channels
Drugs		ATP Debromohymenialdisine Entrectinib Fostamatinib	Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole
Diseases			Atrial fibrillation
GWAS		Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)	Longevity ( 30294719)
Interacting Genes		49 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I
Entrez ID		10188	3741
HPRD ID		06104	08888
Ensembl ID		ENSG00000061938	ENSG00000130037
Uniprot IDs		A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912	P22460
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB
Enriched GO Terms of Interacting Partners?
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