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SIAH1 and NUMB
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
SIAH1
NUMB
Description
siah E3 ubiquitin protein ligase 1
NUMB endocytic adaptor protein
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Nucleus
Cytoplasm
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Basolateral Plasma Membrane
Extrinsic Component Of Plasma Membrane
Clathrin-coated Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Drugs
Diseases
GWAS
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
)
Interacting Genes
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
37 interacting genes:
AP2A1
AP2A2
APP
DNAJC5
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
6477
8650
HPRD ID
03736
04767
Ensembl ID
ENSG00000196470
ENSG00000133961
Uniprot IDs
Q8IUQ4
A0A024R681
A0A024R684
A0A024R6C4
A0A024R6F4
P49757
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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