SIAH1 and UPP2

Data Source:
BioGRID (two hybrid)

		SIAH1	UPP2
Description		siah E3 ubiquitin protein ligase 1	uridine phosphorylase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Cytosol Type III Intermediate Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Uridine Phosphorylase Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Neuron Apoptotic Process Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Uridine Catabolic Process Nucleoside Metabolic Process Nucleotide Catabolic Process Pyrimidine Nucleoside Salvage UMP Salvage Uridine Metabolic Process Pyrimidine Nucleoside Catabolic Process
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Pyrimidine salvage Pyrimidine catabolism
Drugs
Diseases
GWAS		Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	Cerebrospinal P-tau181p levels ( 20932310) Severe gingival inflammation ( 28459102) Sleep duration ( 25469926)
Interacting Genes		151 interacting genes: AASDHPPT AFF1 AFF4 AIMP2 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4-16 HIF1AN HIPK2 HIPK3 INHA IQCN KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PKD1 POU2AF1 PRPF31 PRR20A PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLC9A3R2 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	5 interacting genes: LNX1 MEOX2 MRPL28 SIAH1 VIM
Entrez ID		6477	151531
HPRD ID		03736	15627
Ensembl ID		ENSG00000196470	ENSG00000007001
Uniprot IDs		Q8IUQ4	A0A0S2Z634 A0A0S2Z6U5 O95045
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ	2XRF 3P0E 3P0F
Enriched GO Terms of Interacting Partners?
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