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TNK2 and NPHP1
Data Source:
BioGRID
(pull down)
TNK2
NPHP1
Description
tyrosine kinase non receptor 2
nephrocystin 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Adherens Junction
Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Grb2-EGFR Complex
Cytoophidium
Cytoplasm
Cytosol
Cytoskeleton
Cell-cell Junction
Adherens Junction
Bicellular Tight Junction
Cilium
Membrane
Motile Cilium
Photoreceptor Connecting Cilium
Molecular Function
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
GTPase Inhibitor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Structural Molecule Activity
Protein Binding
Biological Process
Endocytosis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Small GTPase Mediated Signal Transduction
Phosphorylation
Cell Differentiation
Negative Regulation Of GTPase Activity
Innate Immune Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Clathrin-dependent Endocytosis
Signal Transduction
Excretion
Visual Behavior
Cell Projection Organization
Actin Cytoskeleton Organization
Spermatid Differentiation
Retina Development In Camera-type Eye
Protein Localization Involved In Establishment Of Planar Polarity
Ciliary Basal Body-plasma Membrane Docking
Cell-cell Adhesion
Positive Regulation Of Bicellular Tight Junction Assembly
Pathways
Anchoring of the basal body to the plasma membrane
Drugs
ATP
Debromohymenialdisine
Entrectinib
Fostamatinib
Diseases
Joubert syndrome
Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
Senior-Loken syndrome
GWAS
Asthma (
31959851
)
Bronchopulmonary dysplasia (
23897914
)
Low density lipoprotein cholesterol levels (
30498476
)
Total cholesterol levels (
30498476
)
Interacting Genes
49 interacting genes:
AKT1
AQP1
AR
ARSL
BAG3
CDC42
CLTC
CSPG4
CTTN
CYSRT1
DPH2
EGFR
FGFR1
FYN
GALT
GRB2
HCK
HECW1
HSH2D
HSP90AB2P
ITFG2
KCNA5
KRTAP10-3
MAGI3
MCF2
MERTK
NCK1
NEK6
NOTCH2NLA
NPHP1
PDGFRB
PIK3R3
RASGEF1C
RASGRF1
RPL18A
SEZ6
SH2D1A
SH2D1B
SIAH1
SMURF1
SNX9
SOCS4
SRC
SRSF5
VTI1B
WAS
WWOX
WWP2
YES1
16 interacting genes:
ADAM15
ARHGAP32
BCAR1
FBXO7
FLNA
FLNB
FLNC
INVS
KHDRBS1
NPHP3
NPHP4
PAK2
PTK2B
TNK2
TUBB
UBQLN4
Entrez ID
10188
4867
HPRD ID
06104
09524
Ensembl ID
ENSG00000061938
ENSG00000144061
Uniprot IDs
A0A499FJ16
A0A5F9ZGX5
A0A5F9ZHJ2
B3KXJ4
C9J1X3
Q07912
C9JNM7
O15259
PDB IDs
1CF4
1U46
1U4D
1U54
3EQP
3EQR
4EWH
4HZR
4HZS
4ID7
5ZXB
1S1N
6O1Q
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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