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SIAH1 and PRPF31
Data Source:
BioGRID
(two hybrid)
SIAH1
PRPF31
Description
siah E3 ubiquitin protein ligase 1
pre-mRNA processing factor 31
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Nucleus
Nucleoplasm
U2-type Spliceosomal Complex
U4 SnRNP
U4atac SnRNP
Cajal Body
Nuclear Speck
U4/U6 X U5 Tri-snRNP Complex
U2-type Precatalytic Spliceosome
Precatalytic Spliceosome
MLL1 Complex
Spliceosomal Tri-snRNP Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Binding
Protein Binding
U4 SnRNA Binding
U4atac SnRNA Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
SnRNP Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Spliceosomal Tri-snRNP Complex Assembly
MRNA Splicing, Via Spliceosome
SnoRNA Localization
Ribonucleoprotein Complex Localization
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
mRNA Splicing - Major Pathway
Drugs
Diseases
Retinitis pigmentosa (RP)
GWAS
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Change in HbA1c levels in response to metformin treatment in type 2 diabetes (
29650774
)
Interacting Genes
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
135 interacting genes:
ASB15
BHLHB9
BICD2
C1QTNF1
CALCOCO2
CAPNS2
CARD14
CBY2
CCDC106
CCDC136
CCDC33
CCDC57
CCDC70
CCNDBP1
CDC23
CDCA7L
CDR2L
CEP70
CYSRT1
DVL2
DVL3
EFEMP2
EVI5
FANCA
FANCC
FASTK
FLACC1
FSD2
FXR1
GOLGA2
GOLGA6L9
HAP1
HES7
HNRNPH2
HNRNPK
HOOK2
HSF2BP
JAKMIP2
KANK2
KCTD6
KHDRBS2
KHDRBS3
KIFC3
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-8
KRTAP10-9
KRTAP19-5
KRTAP4-11
KRTAP6-3
LBX1
LDOC1
LHX8
LURAP1
LZTS2
MDFI
MEIS3
MEOX2
MID2
MIPOL1
MKRN3
MTUS2
NCAPH2
NCKIPSD
NOTCH2NLA
PAK5
PDE4DIP
PHC2
PHF5A
PICK1
PLEKHG4
PNMA1
PNMA2
PNMA3
PPIH
PPP1R16A
PPP2R3C
PRDM14
PRICKLE1
PRPF3
PSTPIP1
RACK1
RBAK
RBM25
RBM4
RBMX
RBMY1A1
RBMY1F
RBMY1J
REL
RINT1
RUNDC3A
SIAH1
SLAIN1
SNRNP200
SRSF3
SSX2IP
STX11
TADA2A
TFIP11
TLE5
TMCC2
TP53BP2
TRIM14
TRIM23
TRIM27
TRIM41
TSGA10
UBXN11
USH1G
USP15
VWC2
ZFP64
ZFP69B
ZNF24
ZNF250
ZNF408
ZNF417
ZNF473
ZNF48
ZNF587
ZNF668
ZNF71
ZNF774
ZNF792
ZNF837
ZRANB1
ZSCAN22
Entrez ID
6477
26121
HPRD ID
03736
05917
Ensembl ID
ENSG00000196470
ENSG00000105618
Uniprot IDs
Q8IUQ4
Q8WWY3
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
2OZB
3JCR
3SIU
3SIV
5O9Z
6AH0
6AHD
6QW6
6QX9
Enriched GO Terms of Interacting Partners
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