SIAH1 and PKD1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		SIAH1	PKD1
Description		siah E3 ubiquitin protein ligase 1	polycystin 1, transient receptor potential channel interacting
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Plasma Membrane Beta-catenin Destruction Complex	Golgi Membrane Polycystin Complex Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Golgi-associated Vesicle Membrane Motile Cilium Cation Channel Complex Calcium Channel Complex Ciliary Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Calcium Channel Activity Protein Binding Protein Kinase Binding Protein Domain Specific Binding Carbohydrate Binding Wnt-activated Receptor Activity Ion Channel Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Neuron Apoptotic Process Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cartilage Condensation In Utero Embryonic Development Kidney Development Liver Development Embryonic Placenta Development Protein Export From Nucleus Cell Cycle Arrest Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Heart Development Anatomical Structure Morphogenesis Wnt Signaling Pathway Peptidyl-serine Phosphorylation Spinal Cord Development Neural Tube Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Response To Fluid Shear Stress Lymph Vessel Morphogenesis Cytoplasmic Sequestering Of Transcription Factor Skin Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Branching Morphogenesis Of An Epithelial Tube Genitalia Development Detection Of Mechanical Stimulus Cartilage Development Protein Heterotetramerization Regulation Of Mitotic Spindle Organization Lung Epithelium Development Placenta Blood Vessel Development Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Transmembrane Transport Mesonephric Tubule Development Mesonephric Duct Development Metanephric Collecting Duct Development Metanephric Ascending Thin Limb Development Metanephric Proximal Tubule Development Metanephric Distal Tubule Morphogenesis Cell-cell Signaling By Wnt Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases			Polycystic kidney disease
GWAS		Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)	Appendicular lean mass ( 33097823) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494) Major depressive disorder ( 29317602) Neutrophil count ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		151 interacting genes: AASDHPPT AFF1 AFF4 AIMP2 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 DAB1 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4-16 HIF1AN HIPK2 HIPK3 INHA IQCN KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PKD1 POU2AF1 PRPF31 PRR20A PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLC9A3R2 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX	30 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID		6477	5310
HPRD ID		03736	03203
Ensembl ID		ENSG00000196470	ENSG00000008710
Uniprot IDs		Q8IUQ4	P98161
PDB IDs		2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ	1B4R 6A70
Enriched GO Terms of Interacting Partners?
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