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SYP and SIAH1
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro, in vivo, two hybrid)
SYP
SIAH1
Description
synaptophysin
siah E3 ubiquitin protein ligase 1
Image
No pdb structure
GO Annotations
Cellular Component
Synaptic Vesicle
Integral Component Of Synaptic Vesicle Membrane
Synaptic Vesicle Membrane
Neuromuscular Junction
Presynaptic Membrane
Neuron Projection
Terminal Bouton
Perinuclear Region Of Cytoplasm
Presynaptic Active Zone
Excitatory Synapse
Schaffer Collateral - CA1 Synapse
Nucleus
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Beta-catenin Destruction Complex
Molecular Function
Protein Binding
Cholesterol Binding
Syntaxin-1 Binding
SH2 Domain Binding
Identical Protein Binding
Protein Self-association
Ubiquitin-protein Transferase Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
Ubiquitin Conjugating Enzyme Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Endocytosis
Synaptic Vesicle Maturation
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Short-term Neuronal Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Membrane Organization
Cellular Response To Organic Substance
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Opioid Receptor Signaling Pathway
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Nervous System Development
Axon Guidance
Anatomical Structure Morphogenesis
Protein Catabolic Process
Protein Destabilization
Positive Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Metabolic Process
Neuron Apoptotic Process
Negative Regulation Of Netrin-activated Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Netrin-1 signaling
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Height (
28552196
)
Mean corpuscular hemoglobin (
32888494
)
Waist circumference (
28552196
)
Interacting Genes
41 interacting genes:
AP1G1
ARFIP2
CAND2
CD160
DIABLO
FARS2
GAB1
GDNF
GRB2
HSFX1
HSFX2
JOSD2
LNPK
MIEF1
MIEF2
MRM1
MRRF
MTERF3
MYG1
NDRG4
PBX3
PITPNC1
PLIN3
PNKP
PPIF
PTCD1
PTPN9
RBFA
SH3GLB1
SIAH1
SIAH2
SMG9
SNX1
SPG21
SSX5
STARD4
THAP4
TUFM
VAMP2
WDFY2
WIPI2
151 interacting genes:
AASDHPPT
AFF1
AFF4
AIMP2
APC
AQP1
ARMC9
ATN1
ATXN7
AXIN1
BAG1
BAG3
BAG4
BCL6
CACYBP
CAPG
CCDC198
CDC23
CDC34
CDK5R1
DAB1
DCC
DDX41
DNAJC15
DNALI1
EEF1D
EIF3J
ELL2
EXOC3-AS1
FAM90A1
FLI1
FZD9
GAPDH
GDPD5
GRM5
H4-16
HIF1AN
HIPK2
HIPK3
INHA
IQCN
KATNAL1
KCNJ10
KHDRBS3
KIAA0319L
KIAA1217
KIF1B
KIF22
KIFC3
KLF10
LACTB2
LANCL2
LMNA
M1AP
MAB21L1
MAP3K5
MAPK12
MAPKBP1
MAPRE3
MOB3C
MTIF3
MX1
NANOS2
NANOS3
NECTIN2
NELFA
NOL6
NTAQ1
NUMB
NUMBL
OPRM1
OTUB2
PARD6B
PEG10
PEG3
PFKM
PHC1
PHC2
PIAS2
PIAS3
PIMREG
PKD1
POU2AF1
PRPF31
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPMT1
PUF60
PYGB
QRICH1
RAB33A
RAB33B
RAD51AP1
RAD54L2
RAPH1
RBBP8
RPL27A
RPS19BP1
RXRB
SDCBP
SFMBT2
SH3RF1
SLC9A3R2
SNCAIP
SPATA4
SPATC1L
SYP
SYT7
TBC1D22B
TERF2
TFDP1
TMEM43
TNK2
TOLLIP
TP53BP2
TRIM23
TRIM27
TRIM7
TRIM8
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
TXN
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E3
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2V2
UPP2
USP19
UXT
VAV1
ZBP1
ZCCHC10
ZCCHC13
ZFYVE21
ZMAT3
ZNF148
ZNF512B
ZNF671
ZYX
Entrez ID
6855
6477
HPRD ID
02435
03736
Ensembl ID
ENSG00000102003
ENSG00000196470
Uniprot IDs
P08247
Q8IUQ4
PDB IDs
2A25
4C9Z
4CA1
4I7B
4I7C
4I7D
4X3G
5WZZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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