SYP and FARS2

Data Source:
BioGRID (two hybrid)

		SYP	FARS2
Description		synaptophysin	phenylalanyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Cholesterol Binding Syntaxin-1 Binding SH2 Domain Binding Identical Protein Binding Protein Self-association	TRNA Binding Phenylalanine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Endocytosis Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synaptic Vesicle Membrane Organization Cellular Response To Organic Substance Regulation Of Synaptic Vesicle Exocytosis Regulation Of Opioid Receptor Signaling Pathway	TRNA Aminoacylation For Protein Translation Phenylalanyl-tRNA Aminoacylation TRNA Processing
Pathways			Mitochondrial tRNA aminoacylation
Drugs			Phenylalanine
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Copper levels ( 26025379) Height ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 23563609) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
Interacting Genes		41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2	69 interacting genes: ADAMTSL4 AGTRAP AJUBA AP1B1 APPL1 BACH2 BAG4 BANP BEX5 CALCOCO2 CBY2 CCDC152 CDCA4 CMTM5 CYSRT1 DGAT2L6 DPH2 DVL3 FHL5 FKBP7 FSD2 GRB10 HIGD1C HMBOX1 HOMEZ IKZF3 ISY1-RAB43 KCNF1 KCTD17 KRT13 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-3 MAN1C1 MDFI MESD MID2 MKRN3 MORN3 NFKBID NOTCH2NLA PCSK5 PPP1R16B RCBTB2 RIMBP3C SPRY1 STX11 SYP TADA2A TEPSIN TFCP2 TPM2 TRAF2 TRIM27 TRIM54 TRIP6 YIF1A ZNF438 ZNF500 ZNF526 ZNF655 ZRANB1
Entrez ID		6855	10667
HPRD ID		02435	09946
Ensembl ID		ENSG00000102003	ENSG00000145982
Uniprot IDs		P08247	O95363
PDB IDs			3CMQ 3HFV 3TEG 3TUP 5MGH 5MGU 5MGV 5MGW
Enriched GO Terms of Interacting Partners?
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