Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CCL5 and WT1
Data Source:
BioGRID
(two hybrid)
CCL5
WT1
Description
C-C motif chemokine ligand 5
WT1 transcription factor
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
C2H2 Zinc Finger Domain Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Glomerular Visceral Epithelial Cell Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of DNA Methylation
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Transcriptional regulation of testis differentiation
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Blood protein levels (
30072576
28240269
)
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31249589
30194396
31649266
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
64 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
ZNF205
ZRANB1
Entrez ID
6352
7490
HPRD ID
01751
06163
Ensembl ID
ENSG00000271503
ENSG00000184937
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
P19544
Q6PI38
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
1LU6
1XF7
2G7T
2G7V
2G7W
2G7X
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?