WT1 and CEP70

Data Source:
BioGRID (two hybrid)

		WT1	CEP70
Description		WT1 transcription factor	centrosomal protein 70
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Centrosome Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding C2H2 Zinc Finger Domain Binding	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of DNA Methylation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Ciliary Basal Body-plasma Membrane Docking
Pathways		Transcriptional regulation of testis differentiation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Coronary artery disease ( 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pelvic organ prolapse ( 32184442) PR interval ( 32439900) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31249589 30194396 31649266)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Male-pattern baldness ( 28196072)
Interacting Genes		64 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP ZNF205 ZRANB1	242 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DVL3 EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM214B FAM90A1 GADD45GIP1 GAS8 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		7490	80321
HPRD ID		06163	16779
Ensembl ID		ENSG00000184937	ENSG00000114107
Uniprot IDs		P19544 Q6PI38	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY
Enriched GO Terms of Interacting Partners?
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