Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CCL5 and VCAN
Data Source:
HPRD
(in vitro)
CCL5
VCAN
Description
C-C motif chemokine ligand 5
versican
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Photoreceptor Outer Segment
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Membrane
Extracellular Matrix
Interphotoreceptor Matrix
Lysosomal Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Calcium Ion Binding
Protein Binding
Glycosaminoglycan Binding
Hyaluronic Acid Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Carbohydrate Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Skeletal System Development
Osteoblast Differentiation
Cell Adhesion
Multicellular Organism Development
Central Nervous System Development
Cell Recognition
Extracellular Matrix Organization
Chondroitin Sulfate Biosynthetic Process
Chondroitin Sulfate Catabolic Process
Dermatan Sulfate Biosynthetic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Defective B3GALT6 causes EDSP2 and SEMDJL1
Post-translational protein phosphorylation
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Hyaluronic acid
Diseases
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS
Blood protein levels (
30072576
28240269
)
Appendicular lean mass (
28724990
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (MOSTest) (
32665545
)
Carotid intima media thickness (mean) (
31801372
)
Cortical surface area (MOSTest) (
32665545
)
Diisocyanate-induced asthma (
25918132
)
Gastroesophageal reflux disease (
31527586
)
HDL cholesterol levels (
32203549
)
Joint mobility (Beighton score) (
27182965
)
Laryngeal squamous cell carcinoma (
25194280
)
Lean body mass (
28724990
)
Major depressive disorder (
20516156
)
Optic disc size (
31809533
)
Subcortical volume (MOSTest) (
32665545
)
Triglyceride levels (
32203549
)
Vertical cup-disc ratio (
28073927
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter hyperintensity volume (
29752348
)
White matter integrity (fractional anisotropy) (
29752348
32358547
)
White matter integrity (mean diffusivity) (
29752348
32358547
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
24 interacting genes:
ADAMTS1
CCL2
CCL20
CCL21
CCL5
CCL8
CD44
CXCL10
CXCL12
FBLN1
FBLN2
FBN1
HAPLN1
ITGA4
ITGB1
PF4
PLA2G2A
PTPRF
RAB19
SELL
SELP
SELPLG
TNR
XCL1
Entrez ID
6352
1462
HPRD ID
01751
00340
Ensembl ID
ENSG00000271503
ENSG00000038427
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
A0A024RAL1
A0A024RAP3
A0A024RAQ9
P13611
Q59FG9
Q6MZK8
Q86W61
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?