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CCL5 and TGFB1
Data Source:
BioGRID
(two hybrid)
CCL5
TGFB1
Description
C-C motif chemokine ligand 5
transforming growth factor beta 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Plasma Membrane
Microvillus
Cell Surface
Extracellular Matrix
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Blood Microparticle
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Antigen Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Enzyme Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
MAPK Cascade
Vasculogenesis
Epithelial To Mesenchymal Transition
Neural Tube Closure
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Chondrocyte Differentiation
Hematopoietic Progenitor Cell Differentiation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Platelet Degranulation
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Protein Phosphorylation
Protein Export From Nucleus
ATP Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Inflammatory Response
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Common-partner SMAD Protein Phosphorylation
SMAD Protein Complex Assembly
Salivary Gland Morphogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Wounding
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Macrophage Cytokine Production
Positive Regulation Of Microglia Differentiation
Regulation Of Striated Muscle Tissue Development
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Neural Tube Development
Negative Regulation Of Cell-cell Adhesion
Hyaluronan Catabolic Process
Negative Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein-containing Complex Assembly
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Response To Estradiol
Response To Progesterone
Positive Regulation Of Interleukin-17 Production
Receptor Catabolic Process
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Dephosphorylation
Regulation Of Cell Population Proliferation
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Vascular Permeability
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Ossification Involved In Bone Remodeling
Cell-cell Junction Organization
Negative Regulation Of Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cytolysis
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgA Isotypes
Lymph Node Development
Negative Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Chemotaxis
Regulation Of Binding
Regulation Of DNA Binding
Positive Regulation Of Cell Division
Positive Regulation Of Protein Kinase B Signaling
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Blood Vessel Remodeling
Pathway-restricted SMAD Protein Phosphorylation
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Negative Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Biomineral Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Organic Cyclic Compound
Cellular Response To Transforming Growth Factor Beta Stimulus
Extracellular Matrix Assembly
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of NAD+ ADP-ribosyltransferase Activity
Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development
Embryonic Liver Development
Positive Regulation Of Transcription Regulatory Region DNA Binding
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Platelet degranulation
Influenza Virus Induced Apoptosis
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
UCH proteinases
Interleukin-4 and Interleukin-13 signaling
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Hyaluronidase (ovine)
Terazosin
Hyaluronidase (human recombinant)
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Hyaluronidase
Diseases
Graft-versus-host disease
Allograft rejection
Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS
Blood protein levels (
30072576
28240269
)
Colorectal cancer (
27145994
24836286
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
28714974
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Hematuria (
30476138
)
Hematuria (mild) (
30476138
)
Hematuria (moderate to severe) (
30476138
)
Platelet count (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Pulse pressure (
30578418
)
Type 2 diabetes (
31049640
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
95 interacting genes:
ACVRL1
ADAMTSL4
AGR3
ANGPTL4
APC
APP
AURKA
AXIN2
BCAS3
BCL10
BGN
BLID
BMP2
BMP3
BMPR1A
BUB1
CATSPER1
CCDC33
CCL3
CCL5
CCN2
CDKN2A
COL2A1
CST6
CYSRT1
DAXX
DCN
DIRAS3
DLC1
DPT
EGFR
EIF3I
ENG
ERBB2
FBXW7
FCHO1
FCN1
FKBP1A
FMOD
FNTA
GREB1
HOXA1
HOXC6
ITGAV
ITGB6
ITGB8
KLK5
KLK7
KLK9
KRTAP1-1
KRTAP1-3
KRTAP10-8
KRTAP4-11
LAMTOR5
LCE1A
LCE1C
LCE1D
LCE2B
LCE2C
LCE3A
LCE3B
LCE3D
LPXN
LTBP1
LTBP3
LTBP4
MCC
MEOX2
MLH3
MMP2
MTA3
NSD3
P4HB
PDGFRL
PDLIM2
POU4F2
PRSS50
PSMC3IP
PZP
RAPGEF3
SCGB3A1
SDC2
SNAI1
SPARC
ST14
TGFB2
TGFBR1
TGFBR2
TGFBR3
THBS1
THRSP
TLR2
VASN
VTN
YWHAE
Entrez ID
6352
7040
HPRD ID
01751
01821
Ensembl ID
ENSG00000271503
ENSG00000105329
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
A0A499FJK2
P01137
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
1KLA
1KLC
1KLD
3KFD
4KV5
5FFO
5VQP
6OM2
6P7J
Enriched GO Terms of Interacting Partners
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