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CCL5 and CCR5
Data Source:
BioGRID
(pull down)
HPRD
(in vivo, in vitro)
CCL5
CCR5
Description
C-C motif chemokine ligand 5
C-C motif chemokine receptor 5
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytoplasm
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Virus Receptor Activity
Actin Binding
Phosphatidylinositol Phospholipase C Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Identical Protein Binding
Chemokine (C-C Motif) Ligand 5 Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
Calcium-mediated Signaling
Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Maraviroc
AMD-070
CCR5 mAb
Leronlimab
Aplaviroc
Vicriviroc
Ibalizumab
INCB-9471
Diseases
GWAS
Blood protein levels (
30072576
28240269
)
Blood protein levels (
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
20190752
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
43 interacting genes:
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
EMP1
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GRK2
GRK3
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
SLC20A2
STAT1
STAT3
STAT5A
TXK
Entrez ID
6352
1234
HPRD ID
01751
03223
Ensembl ID
ENSG00000271503
ENSG00000160791
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
P51681
Q38L21
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
1ND8
1NE0
1OPN
1OPT
1OPW
2L87
2MZX
2RLL
2RRS
4MBS
5UIW
5YD3
5YD4
5YD5
5YY4
6FGP
6MEO
6MET
Enriched GO Terms of Interacting Partners
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