Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
WT1 and CYSRT1
Data Source:
BioGRID
(two hybrid)
WT1
CYSRT1
Description
WT1 transcription factor
cysteine rich tail 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
C2H2 Zinc Finger Domain Binding
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Glomerular Visceral Epithelial Cell Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of DNA Methylation
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
Transcriptional regulation of testis differentiation
Drugs
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31249589
30194396
31649266
)
Interacting Genes
64 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
ZNF205
ZRANB1
497 interacting genes:
A1CF
ACY3
ADAM12
ADAMTSL3
ADAMTSL4
ADAMTSL5
AGXT
ALDH3B1
ALPP
ANAPC11
ANKS1A
AQP1
AREG
ARHGAP33
ARHGAP9
ARID5A
ASTL
ATG9A
ATPAF2
ATXN7L2
AVPI1
B4GALT7
BAG3
BAG6
BAHD1
BAIAP2L1
BEX1
BEX2
BLCAP
BMP7
BRME1
BSCL2
C11orf16
C11orf87
C19orf54
C22orf39
C4orf45
C7orf31
C9orf24
CACNA1A
CACNA1S
CARD10
CARHSP1
CATSPER1
CBLL2
CBX2
CCDC120
CCDC187
CCDC28A-AS1
CCER1
CCNK
CD300LG
CDKL3
CELF5
CERCAM
CERK
CES1
CFAP206
CFP
CHCHD2
CHCHD3
CHIC2
CHRD
CHRNG
CLCNKA
CLDN19
CLDN2
CLEC18A
CNNM3
CNTF
COA5
COL8A1
COMP
CRCT1
CREB5
CRH
CRY2
CRYBA1
CRYBA2
CSF1
CST2
CST9L
CTRC
CTSG
CTSZ
CXCL16
CYP21A2
DACT2
DALRD3
DBF4B
DCDC2B
DDX43
DLGAP2
DMRT3
DNAJA3
DNASE1L3
DOCK2
DVL3
ECE1
ECM1
EFEMP1
EFEMP2
EMC7
ENKD1
EPS8L1
ERH
ESR2
ETNK2
FADS6
FAM102A
FAM124B
FAM214B
FAM221A
FAM221B
FAM71C
FAM83A
FAM90A1
FARS2
FASLG
FBXW5
FEZF1
FHL3
FOXD2
FOXD4L1
FOXD4L3
FOXH1
FRS3
FRZB
FZD10
GAS8
GATA2
GATA3
GATA5
GCSAM
GEM
GGN
GLB1L2
GLP1R
GNE
GNG13
GPANK1
GPATCH2L
GPRIN2
GPS2
GRN
GSTP1
GUCD1
HBZ
HCK
HDHD3
HEY2
HHEX
HLX
HOXA1
HOXB5
HOXB9
HOXC8
HOXC9
HR
HRG
HSBP1
HSD3B7
HSPA12B
HSPD1
HYAL2
HYPK
ICAM1
ICAM4
IL16
INCA1
INO80B
INPP5D
INS
IQCN
IQUB
ITGB2
ITGB4
ITGB5
JOSD1
KCNS2
KCTD15
KLHL38
KLK8
KPRP
KRT20
KRT31
KRT33B
KRT34
KRT81
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-2
KRTAP13-3
KRTAP13-4
KRTAP15-1
KRTAP19-1
KRTAP19-2
KRTAP19-3
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-1
KRTAP3-3
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
KRTAP9-2
KRTAP9-3
KRTAP9-8
KSR2
LAGE3
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LENG8
LGALS9C
LMF2
LMNTD2
LMO3
LMO4
LNX1
LONRF1
LONRF3
LRFN4
LRRC29
LRRC41
LRRN4
LYVE1
MACROH2A1
MAPKBP1
MCRS1
MED25
MELTF
MEOX2
MFSD13A
MGAT5B
MIIP
MKRN3
MRPL23
MRPL40
MSRB1
MT1M
MTA1
MTNR1A
MXD3
MXI1
MYPOP
NBPF19
NDUFA9
NDUFAF3
NECTIN2
NECTIN3
NEU2
NEU4
NKD1
NMU
NOTCH2NLA
NOXA1
NPBWR2
NPDC1
NPPB
NR1D2
NR4A3
NSD1
NTAQ1
NTN4
NUBP2
NUFIP2
OLIG3
OR7A17
OTOS
OTX1
P2RX7
PATZ1
PCSK5
PDE9A
PGAP2
PGAP6
PHETA1
PHLDA1
PITX1
PITX2
PKD2
PKN1
PLA2G10
PLAC8
PLEKHN1
PLLP
POU4F2
PPP1CB
PPP1R32
PPY
PRF1
PRKAA2
PRKAB2
PROC
PROP1
PRPF31
PRR19
PRR22
PRR30
PRR34
PRR35
PTGDS
PTPMT1
PVR
QRICH1
R3HDM2
RAB3IL1
RALGDS
RAMAC
RAMP3
RASD1
RBM22
RBP3
RECK
REM2
RGL2
RGS3
RHBG
RHNO1
RNF38
RPS19BP1
RPUSD3
RSPO2
SAPCD2
SAXO1
SCARF1
SCNM1
SEMA3B
SEMA4C
SH3KBP1
SH3RF2
SHFL
SHISA6
SLC12A4
SLC13A5
SLC23A1
SLC25A18
SLC25A48
SLC43A2
SLC5A5
SLC6A20
SLIT1
SMARCC1
SMARCD1
SMARCE1
SMCP
SMOC1
SMUG1
SNRPB
SNRPC
SNX18
SOCS7
SPATA24
SPATA3
SPATA46
SPATA8
SPEF1
SPG7
SPON1
SPPL2C
SPRY1
SPTSSA
SRD5A2
SSC4D
STK16
TAPBPL
TBX2
TBX6
TCAF1
TCEA2
TCEANC
TCF7L2
TENT5B
TEPSIN
TEX37
TEX45
TFAP2D
TGFB1
THAP7
TIMM22
TLE5
TM7SF2
TMEM174
TNIP1
TNIP3
TNK2
TNS4
TRAPPC14
TREX1
TRIM42
TSGA10IP
TSPAN4
TTC23
TTPA
TYK2
UBXN7
USP54
UTP23
VASN
VENTX
VGLL3
VSTM4
VWC2
VWC2L
WDR25
WIF1
WNT11
WT1
YPEL3
YY1
ZBTB25
ZBTB4
ZCCHC14
ZDHHC1
ZFHX2
ZIC1
ZMYND10
ZNF124
ZNF266
ZNF319
ZNF330
ZNF34
ZNF408
ZNF414
ZNF417
ZNF419
ZNF438
ZNF439
ZNF440
ZNF441
ZNF446
ZNF497
ZNF552
ZNF575
ZNF580
ZNF581
ZNF587
ZNF648
ZNF669
ZNF683
ZNF696
ZNF764
ZNF775
ZNF786
ZNF835
ZNF837
ZNF843
ZNHIT1
ZSCAN5A
Entrez ID
7490
375791
HPRD ID
06163
14696
Ensembl ID
ENSG00000184937
ENSG00000197191
Uniprot IDs
P19544
Q6PI38
A8MQ03
B8A4K4
PDB IDs
1LU6
1XF7
2G7T
2G7V
2G7W
2G7X
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?