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CCL5 and RANGAP1
Data Source:
BioGRID
(two hybrid)
CCL5
RANGAP1
Description
C-C motif chemokine ligand 5
Ran GTPase activating protein 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Kinetochore
Condensed Chromosome Kinetochore
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Dendrite
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Nuclear Pore Cytoplasmic Filaments
Perinuclear Region Of Cytoplasm
Mitotic Spindle
Axon Cytoplasm
Cytoplasmic Periphery Of The Nuclear Pore Complex
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
RNA Binding
GTPase Activator Activity
Protein Binding
Small GTPase Binding
Ubiquitin Protein Ligase Binding
Cadherin Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Signal Transduction
Protein Sumoylation
Negative Regulation Of Protein Export From Nucleus
Response To Axon Injury
Activation Of GTPase Activity
Cellular Response To Vasopressin
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMO E3 ligases SUMOylate target proteins
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Mitotic Prometaphase
Postmitotic nuclear pore complex (NPC) reformation
EML4 and NUDC in mitotic spindle formation
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Diseases
GWAS
Blood protein levels (
30072576
28240269
)
Adventurousness (
30643258
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bitter beverage consumption (
31046077
)
Heel bone mineral density (
30598549
)
Lamb consumption (
32066663
)
Medication use (adrenergics, inhalants) (
31015401
)
Mood instability (
31168069
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Schizophrenia (
28991256
25056061
29483656
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
20 interacting genes:
AXIN2
CCL5
CSNK2A1
DLC1
GNAI1
GNAI3
IPO8
MUL1
PDGFRL
PTEN
RAN
RANBP2
SENP1
SENP2
SUMO1
SUMO2
SUMO3
UBE2E3
UBE2I
USPL1
Entrez ID
6352
5905
HPRD ID
01751
03839
Ensembl ID
ENSG00000271503
ENSG00000100401
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
A0A024R1U0
P46060
Q9BSK3
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2IO2
2IO3
2IY0
3UIN
3UIO
3UIP
5D2M
Enriched GO Terms of Interacting Partners
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