WT1 and CASZ1

Data Source:
BioGRID (two hybrid)

		WT1	CASZ1
Description		WT1 transcription factor	castor zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of DNA Methylation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Regulation Of Transcription, DNA-templated Multicellular Organism Development Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional regulation of testis differentiation
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Coronary artery disease ( 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pelvic organ prolapse ( 32184442) PR interval ( 32439900) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31249589 30194396 31649266)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Apolipoprotein B levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Beard thickness ( 26926045) Blood pressure ( 21572416) Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878 29403010 28739976 27618447 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology ( 31763980) Hypertension ( 25249183 30487518) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Male-pattern baldness ( 28196072) Mean arterial pressure ( 29403010 27618448 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Resistant hypertension ( 31545351) Stroke ( 29531354) Systolic blood pressure ( 19430479 27841878 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 26631737 31511532) White blood cell count ( 32888494)
Interacting Genes		64 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP ZNF205 ZRANB1	9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1
Entrez ID		7490	54897
HPRD ID		06163	07897
Ensembl ID		ENSG00000184937	ENSG00000130940
Uniprot IDs		P19544 Q6PI38	B3KRV8 Q86V15
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?