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CCL5 and PHB
Data Source:
BioGRID
(two hybrid)
CCL5
PHB
Description
C-C motif chemokine ligand 5
prohibitin
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
Mitochondrial Crista
Extrinsic Component Of Mitochondrial Outer Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Extrinsic Component Of Presynaptic Active Zone Membrane
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Protein Kinase Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Receptor Signaling Protein Tyrosine Kinase Activator Activity
CCR1 Chemokine Receptor Binding
CCR4 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Chemokine Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Self-association
Chemokine Receptor Antagonist Activity
CCR Chemokine Receptor Binding
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Regulation Of Chronic Inflammatory Response
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Leukocyte Cell-cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Positive Regulation Of Activation Of Janus Kinase Activity
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Cellular Biosynthetic Process
Activation Of Phospholipase D Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of T Cell Proliferation
Neutrophil Activation
Positive Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Translational Initiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Insulin Secretion
Regulation Of T Cell Activation
Positive Chemotaxis
Positive Regulation Of Calcium Ion Transport
Positive Regulation Of Protein Tyrosine Kinase Activity
Chemokine-mediated Signaling Pathway
Negative Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Neuron Death
Positive Regulation Of T Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Ovarian Follicle Atresia
Osteoblast Differentiation
Immunoglobulin Production
Regulation Of Transcription, DNA-templated
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Signal Transduction
Activation Of Phospholipase C Activity
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Death
Negative Regulation Of Transcription By Competitive Promoter Binding
Histone Deacetylation
CD40 Signaling Pathway
Negative Regulation Of Cell Growth
Animal Organ Regeneration
Interleukin-17 Production
Response To Immobilization Stress
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Response To Drug
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Modulation By Host Of Viral RNA Genome Replication
Response To Ethanol
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Viral Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of NIK/NF-kappaB Signaling
Activation Of Protein Kinase C Activity
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Drugs
Heparin Disaccharide I-S
Heparin Disaccharide Iii-S
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Blood protein levels (
30072576
28240269
)
Asthma (
31959851
30929738
32296059
29273806
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Cancer (
29299148
)
Coronary artery disease (
29212778
33020668
)
Diastolic blood pressure (
19430483
27841878
)
Lower body strength (
27325353
)
Metabolite levels (
23823483
)
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Restricted and repetitive behaviours in autism spectrum disorder (
28533516
)
Systolic blood pressure (
27841878
30578418
)
Interacting Genes
55 interacting genes:
ACKR1
ACKR2
ACKR4
APC
BAG4
BCAR3
CCL11
CCL13
CCL16
CCL17
CCL2
CCL20
CCL21
CCL24
CCL25
CCL26
CCL27
CCL28
CCR1
CCR3
CCR4
CCR5
CHEK2
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
DPP4
EDC4
FZR1
GRB2
IGFBP7
KRAS
PALB2
PF4
PHB
PIGR
PPBP
PTPN1
RANGAP1
RELA
SDC1
SDC4
SLC2A5
TGFB1
TRIP6
VCAN
WT1
XCL1
XCL2
25 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
Entrez ID
6352
5245
HPRD ID
01751
01454
Ensembl ID
ENSG00000271503
ENSG00000167085
Uniprot IDs
A0A494C1Q1
D0EI67
P13501
A8K401
P35232
Q53FV0
PDB IDs
1B3A
1EQT
1HRJ
1RTN
1RTO
1U4L
1U4M
1U4P
1U4R
2L9H
2VXW
5CMD
5COY
5DNF
5L2U
5UIW
6AEZ
6C6D
6FGP
6LOG
6STK
1LU7
Enriched GO Terms of Interacting Partners
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