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WT1 and EGR1
Data Source:
BioGRID
(pull down)
WT1
EGR1
Description
WT1 transcription factor
early growth response 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
C2H2 Zinc Finger Domain Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Histone Acetyltransferase Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Glomerular Visceral Epithelial Cell Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of DNA Methylation
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Response To Ischemia
Regulation Of Transcription By RNA Polymerase II
Response To Glucose
Positive Regulation Of Gene Expression
T Cell Differentiation
BMP Signaling Pathway
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-1 Beta Production
Response To Insulin
Circadian Regulation Of Gene Expression
Regulation Of Protein Sumoylation
Skeletal Muscle Cell Differentiation
Regulation Of Apoptotic Process
Estrous Cycle
Locomotor Rhythm
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Circadian Temperature Homeostasis
Type I Interferon Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Cellular Response To Gamma Radiation
Cellular Response To Heparin
Cellular Response To Mycophenolic Acid
Glomerular Mesangial Cell Proliferation
Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation
Negative Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-8
Positive Regulation Of Neuron Death
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Tau-protein Kinase Activity
Regulation Of Progesterone Biosynthetic Process
Pathways
Transcriptional regulation of testis differentiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
NGF-stimulated transcription
NGF-stimulated transcription
Interferon alpha/beta signaling
Drugs
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31249589
30194396
31649266
)
Amyotrophic lateral sclerosis (C9orf72 mutation interaction) (
22959728
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia (
29274321
)
Schizophrenia (
28991256
25056061
)
Interacting Genes
64 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
ZNF205
ZRANB1
23 interacting genes:
CDKN2A
CEBPB
CRBN
CREBBP
CSNK2A1
DNMT3L
EP300
ERBB3
IL1B
JUN
MTDH
NAB1
NAB2
NFATC1
NFATC2
PITX1
PSMA3
RELA
SP1
SRA1
SREBF2
TP53
WT1
Entrez ID
7490
1958
HPRD ID
06163
00549
Ensembl ID
ENSG00000184937
ENSG00000120738
Uniprot IDs
P19544
Q6PI38
P18146
Q546S1
PDB IDs
1LU6
1XF7
2G7T
2G7V
2G7W
2G7X
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
4R2A
4R2C
4R2D
4X9J
5N14
Enriched GO Terms of Interacting Partners
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