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RPA2 and ATM
Data Source:
BioGRID
(enzymatic study)
RPA2
ATM
Description
replication protein A2
ATM serine/threonine kinase
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
DNA Repair Complex
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Response To Hypoxia
Somitogenesis
Pre-B Cell Allelic Exclusion
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Brain Development
Heart Development
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Histone Phosphorylation
V(D)J Recombination
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Neuron Apoptotic Process
Regulation Of Telomerase Activity
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Catabolic Process
Regulation Of Microglial Cell Activation
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Regulation Of Cellular Response To Gamma Radiation
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Drugs
Caffeine
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
Chronic lymphocytic leukemia (CLL)
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Monocyte count (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Interacting Genes
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
98 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
ATR
BCAS3
BCL10
BRCA1
BRCA2
CDC6
CDKN2C
CHD4
CHEK1
CHEK2
COPS5
CREB1
CRX
CSNK1D
CXXC5
DAXX
DCAF1
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FOXO3
H2AX
HIF1A
HSPA8
IL24
KAT5
KAT8
LIG4
MAP1S
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
NBN
NR4A1
NREP
NSD3
OSGIN1
PARP1
PEX5
POLR2A
PPP2R5C
PRKDC
PTCH1
RAD17
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
SMC1A
SPSB1
STK11
TCL1A
TELO2
TERF1
TERF2
TFF1
TIPARP
TOP1
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
UCHL3
WRN
XPA
XRCC5
ZEB1
ZNF821
Entrez ID
6118
472
HPRD ID
01566
06347
Ensembl ID
ENSG00000117748
ENSG00000149311
Uniprot IDs
B4DUL2
P15927
A0A024R3C7
Q13315
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
5NP0
5NP1
6HKA
6K9K
6K9L
Enriched GO Terms of Interacting Partners
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