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RPA2 and COPS6
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
RPA2
COPS6
Description
replication protein A2
COP9 signalosome subunit 6
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleoplasm
Cytosol
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
Protein Binding
Metallopeptidase Activity
Isopeptidase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
Protein Deneddylation
Nucleotide-excision Repair, DNA Damage Recognition
Transcription-coupled Nucleotide-excision Repair
Viral Process
Post-translational Protein Modification
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
93 interacting genes:
ANXA1
ANXA7
ASH2L
BFSP2
BTBD2
C1orf174
C4orf17
CASP3
CASP6
CASP7
CASP8
CCBE1
CCDC106
CDH10
CDKN1A
CDKN2C
CHRNB1
COPS2
COPS3
COPS4
COPS5
COPS7B
COPS8
COPS9
COX17
COX5A
CRELD1
CUL1
CUL5
DIS3L2
DLEU1
EDN1
EIF3E
EMD
EP300
ERH
FAU
GPS1
HMOX2
LAMA4
LPL
MAP3K1
MAP7D1
MAPK1
MAPK6
MAPKAPK3
MIF
MNAT1
MYCBP
NEDD8
NR3C1
ORAI2
PAEP
PAFAH1B3
PBX2
PDZK1IP1
PFKL
PHYHIP
PMF1
PRKRA
PSAP
PSMD11
PTEN
QTRT1
RAB27A
RBX1
RFC5
ROGDI
RPA2
RPL15
S100A10
SAT1
SERPINA5
SERPINB9
SHC3
SLC2A1
SMN1
SNRPG
STK40
STX5
SULT1E1
TDGF1
TK1
TP53
TP63
TRDMT1
TRIB3
USHBP1
VIM
WIPI2
ZEB2
ZFHX3
ZNF24
Entrez ID
6118
10980
HPRD ID
01566
16735
Ensembl ID
ENSG00000117748
ENSG00000168090
Uniprot IDs
B4DUL2
P15927
Q7L5N1
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
4D10
4D18
4QFT
4R14
4WSN
6R6H
6R7F
6R7H
6R7I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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