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ATM and RASSF1
Data Source:
BioGRID
(unspecified method)
ATM
RASSF1
Description
ATM serine/threonine kinase
Ras association domain family member 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
DNA Repair Complex
Spindle Pole
Nucleus
Cytoplasm
Microtubule Organizing Center
Microtubule
Microtubule Cytoskeleton
Molecular Function
DNA Binding
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Zinc Ion Binding
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Response To Hypoxia
Somitogenesis
Pre-B Cell Allelic Exclusion
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Brain Development
Heart Development
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Histone Phosphorylation
V(D)J Recombination
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Neuron Apoptotic Process
Regulation Of Telomerase Activity
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Catabolic Process
Regulation Of Microglial Cell Activation
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Regulation Of Cellular Response To Gamma Radiation
Cell Cycle Arrest
Signal Transduction
Ras Protein Signal Transduction
Regulation Of Microtubule Cytoskeleton Organization
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Drugs
Caffeine
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
Chronic lymphocytic leukemia (CLL)
Non-small cell lung cancer
Bladder cancer
Nasopharyngeal cancer
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Monocyte count (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Basophil percentage of white cells (
32888494
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (
28991256
30285260
)
Sleep duration (short sleep) (
30846698
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
98 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
ATR
BCAS3
BCL10
BRCA1
BRCA2
CDC6
CDKN2C
CHD4
CHEK1
CHEK2
COPS5
CREB1
CRX
CSNK1D
CXXC5
DAXX
DCAF1
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FOXO3
H2AX
HIF1A
HSPA8
IL24
KAT5
KAT8
LIG4
MAP1S
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
NBN
NR4A1
NREP
NSD3
OSGIN1
PARP1
PEX5
POLR2A
PPP2R5C
PRKDC
PTCH1
RAD17
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
SMC1A
SPSB1
STK11
TCL1A
TELO2
TERF1
TERF2
TFF1
TIPARP
TOP1
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
UCHL3
WRN
XPA
XRCC5
ZEB1
ZNF821
70 interacting genes:
AKT1
ARAF
ATM
ATP2B4
ATR
ATRX
AURKA
AURKB
BRAF
C7orf25
C8orf33
CCND2
CCNE1
CDC20
CDK4
CDK6
CDKN2A
CDKN2B
CLNK
CNKSR1
DAXX
DDB1
E4F1
EPHA2
ERBB2
EXOSC8
FGFR4
FZR1
GLIS2
GRM1
HRAS
IGFBP5
KAT2A
KCNE3
KDELR2
KDM1A
LATS2
MAP1B
MAP1S
MAP2K3
MAP2K6
MAPK8
MDM2
MET
MOAP1
MST1
MYC
NF2
NUDT10
PRKDC
RAF1
RASSF5
RELA
RHOA
RHOU
SAV1
SMARCA4
STK11
STK3
STK4
SUV39H1
SUV39H2
TEAD2
TERT
TNFRSF10A
TNFRSF1A
TSC1
TUBB
TUBG1
XPA
Entrez ID
472
11186
HPRD ID
06347
05470
Ensembl ID
ENSG00000149311
ENSG00000068028
Uniprot IDs
A0A024R3C7
Q13315
Q9NS23
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
2KZU
Enriched GO Terms of Interacting Partners
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