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RPA2 and PCM1
Data Source:
BioGRID
(two hybrid)
RPA2
PCM1
Description
replication protein A2
pericentriolar material 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Pericentriolar Material
Cytoplasm
Centrosome
Centriole
Cytosol
Membrane
Nuclear Membrane
Protein-containing Complex
Centriolar Satellite
Ciliary Transition Zone
Ciliary Basal Body
Apical Part Of Cell
Non-motile Cilium
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
Protein Binding
Identical Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Neuron Migration
Centrosome Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Interkinetic Nuclear Migration
Cytoplasmic Microtubule Organization
Microtubule Anchoring
Microtubule Anchoring At Centrosome
Social Behavior
Intraciliary Transport Involved In Cilium Assembly
Negative Regulation Of Neurogenesis
Cilium Assembly
Protein Localization To Centrosome
Positive Regulation Of Intracellular Protein Transport
Neuronal Stem Cell Population Maintenance
Ciliary Basal Body-plasma Membrane Docking
Non-motile Cilium Assembly
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Atrial fibrillation (
28416818
)
Economic and political preferences (
22566634
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Triglyceride levels (
32203549
)
Waist-hip ratio (
30108283
)
Weight (
28552196
)
Interacting Genes
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
43 interacting genes:
ABI1
ABI2
AKAP9
BBS4
CASK
CCDC172
CCHCR1
CDC42
CEP72
CYTH4
DDIT3
DDX23
DYNLL1
E2F4
ECPAS
EPS8
EXOC8
FAM81A
FXR2
GABARAP
GOLGA2
HAP1
ING5
KLC1
KLC4
KRT15
KRT19
KRT24
MCRS1
NDC80
NECAB2
PCNT
PRC1
PRKCI
RALBP1
RBM5
RINT1
RPA2
TFIP11
TTC8
WASHC3
YWHAE
YWHAQ
Entrez ID
6118
5108
HPRD ID
01566
02624
Ensembl ID
ENSG00000117748
ENSG00000078674
Uniprot IDs
B4DUL2
P15927
A2RUU9
B9EIS5
Q15154
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
6HYL
6HYM
Enriched GO Terms of Interacting Partners
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