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RPA2 and XPA
Data Source:
HPRD
(in vitro)
RPA2
XPA
Description
replication protein A2
XPA, DNA damage recognition and repair factor
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Intercellular Bridge
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
UV Protection
Response To Auditory Stimulus
Nucleotide-excision Repair, DNA Incision
Protein Localization To Nucleus
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Interacting Genes
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC4
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
Entrez ID
6118
7507
HPRD ID
01566
02045
Ensembl ID
ENSG00000117748
ENSG00000136936
Uniprot IDs
B4DUL2
P15927
P23025
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
Enriched GO Terms of Interacting Partners
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