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RPA2 and AKAP9
Data Source:
BioGRID
(two hybrid)
RPA2
AKAP9
Description
replication protein A2
A-kinase anchoring protein 9
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Nuclear Body
PML Body
Site Of Double-strand Break
Golgi Apparatus
Golgi Stack
Cis-Golgi Network
Centrosome
Cytosol
Cytoskeleton
Voltage-gated Potassium Channel Complex
Intracellular Membrane-bounded Organelle
Synaptic Membrane
Glutamatergic Synapse
Molecular Function
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Protein N-terminus Binding
G-rich Strand Telomeric DNA Binding
DNA Binding
Signaling Receptor Binding
Protein Binding
Potassium Channel Regulator Activity
Protein Kinase A Regulatory Subunit Binding
Ion Channel Binding
Molecular Adaptor Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Regulation Of Double-strand Break Repair Via Homologous Recombination
Translesion Synthesis
Mitotic G1 DNA Damage Checkpoint
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of DNA Damage Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Microtubule Nucleation
Signal Transduction
Chemical Synaptic Transmission
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Microtubule Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Maintenance Of Centrosome Location
Regulation Of Membrane Repolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Cardiac Conduction
Cellular Response To CAMP
Regulation Of Heart Rate By Cardiac Conduction
Ciliary Basal Body-plasma Membrane Docking
Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction
Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Golgi Organization
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Phase 3 - rapid repolarisation
Phase 2 - plateau phase
Anchoring of the basal body to the plasma membrane
Signaling by BRAF and RAF fusions
AURKA Activation by TPX2
Drugs
Diseases
Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS
HDL cholesterol levels (
32203549
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
White blood cell count (
32888494
)
Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) (
24236485
)
Breast cancer (
29059683
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Cerebrospinal fluid t-tau levels in mild cognitive impairment (
29274321
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Red blood cell count (
32888494
)
Interacting Genes
63 interacting genes:
ACP5
AKAP9
APP
ATM
CALCOCO2
CASK
CCNC
CCNO
CDC5L
CDK1
CEP126
CFB
COPS6
CRMP1
DMRTB1
EEF1A1
EIF4G2
ERCC1
ERCC4
GAPDH
GOLM1
HERPUD1
HNRNPUL1
HUS1
LNX2
LRIF1
MARK2
MCM2
MCM5
MED1
MED31
MEN1
NDEL1
ORC1
ORC2
ORC4
ORC5
PCM1
PPP4C
PRC1
PRKCI
PRKDC
RAD1
RAD51
RAD52
RAD9A
RBM14
RBM48
RPA1
RPA3
RPLP1
SDF4
SERTAD3
SLC17A9
STAT3
TLE1
TUBB2A
UNC119
UNG
UTP14A
XPA
YWHAE
ZBTB14
85 interacting genes:
ABI2
BEX2
BLZF1
C1orf94
CALM1
CALM2
CALM3
CASK
CCDC116
CCDC146
CCP110
CDC5L
CEP55
CLIC1
CSNK1D
CSNK1E
CTBP1
CTNNA3
DVL2
FAM90A1
FMR1
FNBP1
FXR2
GLIS2
GPC4
GRIN1
GTSE1
HDDC3
HNRNPM
IKZF3
KCNQ1
KDM1A
KIF19
KLC4
LMO1
MAGEA6
MAGED1
MED1
MYO5A
NDEL1
PARD6G
PCM1
PCNT
PKN1
PKP2
PPP1CA
PPP2R1B
PPP2R3A
PRC1
PRDM14
PRKAR2A
PRKAR2B
PRKCE
RBM10
RBM14
RPA2
RSRC2
SAMD3
SCNM1
SF3B2
SLAIN1
SNF8
SNRPB
SSX2
SSX3
SSX5
SUV39H2
TACC3
TCEANC
TDP2
TENT5B
THAP1
THOC1
TLX3
TNIK
TRIP10
TSG101
TSNAX
TUBGCP3
TULP3
USHBP1
USO1
VPS9D1
WAC
YWHAE
Entrez ID
6118
10142
HPRD ID
01566
04921
Ensembl ID
ENSG00000117748
ENSG00000127914
Uniprot IDs
B4DUL2
P15927
Q5GIA7
Q6PJH3
Q99996
PDB IDs
1DPU
1L1O
1QUQ
1Z1D
2PI2
2PQA
2Z6K
3KDF
4MQV
4OU0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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