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ATM and H2AX
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
ATM
H2AX
Description
ATM serine/threonine kinase
H2A.X variant histone
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
DNA Repair Complex
Chromosome, Telomeric Region
Nucleosome
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Centrosome
Nuclear Speck
Site Of Double-strand Break
Extracellular Exosome
Site Of DNA Damage
Molecular Function
DNA Binding
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Ovarian Follicle Development
Response To Hypoxia
Somitogenesis
Pre-B Cell Allelic Exclusion
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint
Reciprocal Meiotic Recombination
Male Meiotic Nuclear Division
Female Meiotic Nuclear Division
Signal Transduction
Brain Development
Heart Development
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To Ionizing Radiation
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Histone Phosphorylation
V(D)J Recombination
Multicellular Organism Growth
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Lipoprotein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Neuron Apoptotic Process
Meiotic Telomere Clustering
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Thymus Development
Oocyte Development
Neuron Apoptotic Process
Regulation Of Telomerase Activity
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Catabolic Process
Regulation Of Microglial Cell Activation
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Regulation Of Cellular Response To Gamma Radiation
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
Chromatin Silencing
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Viral Process
Cerebral Cortex Development
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Cellular Response To Gamma Radiation
Cellular Senescence
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Caffeine
Diseases
Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
Chronic lymphocytic leukemia (CLL)
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Monocyte count (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Interacting Genes
98 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
ATR
BCAS3
BCL10
BRCA1
BRCA2
CDC6
CDKN2C
CHD4
CHEK1
CHEK2
COPS5
CREB1
CRX
CSNK1D
CXXC5
DAXX
DCAF1
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FOXO3
H2AX
HIF1A
HSPA8
IL24
KAT5
KAT8
LIG4
MAP1S
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
NBN
NR4A1
NREP
NSD3
OSGIN1
PARP1
PEX5
POLR2A
PPP2R5C
PRKDC
PTCH1
RAD17
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
SMC1A
SPSB1
STK11
TCL1A
TELO2
TERF1
TERF2
TFF1
TIPARP
TOP1
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
UCHL3
WRN
XPA
XRCC5
ZEB1
ZNF821
46 interacting genes:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
EYA1
HUWE1
KAT5
MASP1
MDC1
MRE11
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PRKDC
PTPA
QARS1
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TRAF6
TSSK6
WRN
Entrez ID
472
3014
HPRD ID
06347
03465
Ensembl ID
ENSG00000149311
ENSG00000188486
Uniprot IDs
A0A024R3C7
Q13315
P16104
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
1YDP
2AZM
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
6K1I
6K1J
6K1K
Enriched GO Terms of Interacting Partners
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