ATM and TRAF6

Data Source:
BioGRID (pull down)

		ATM	TRAF6
Description		ATM serine/threonine kinase	TNF receptor associated factor 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle DNA Repair Complex	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex
	Molecular Function	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Identical Protein Binding Protein-containing Complex Binding Protein N-terminus Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Ovarian Follicle Development Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Replication Double-strand Break Repair Via Nonhomologous End Joining Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiotic Nuclear Division Signal Transduction Brain Development Heart Development Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To Ionizing Radiation Regulation Of Autophagy Positive Regulation Of Gene Expression Histone Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of B Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Histone Phosphorylation V(D)J Recombination Multicellular Organism Growth Phosphatidylinositol-3-phosphate Biosynthetic Process Peptidyl-serine Autophosphorylation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Meiotic Telomere Clustering Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Thymus Development Oocyte Development Neuron Apoptotic Process Regulation Of Telomerase Activity Histone MRNA Catabolic Process Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Cellular Response To X-ray Cellular Response To Nitrosative Stress Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Catabolic Process Regulation Of Microglial Cell Activation Negative Regulation Of TORC1 Signaling Negative Regulation Of Telomere Capping Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomerase Catalytic Core Complex Assembly Regulation Of Cellular Response To Gamma Radiation	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Protein Deubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Fc-epsilon Receptor Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Meiotic recombination Pexophagy	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs		Caffeine
Diseases		Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Chronic lymphocytic leukemia (CLL)
GWAS		Alzheimer's disease (late onset) ( 28714976) Cutaneous malignant melanoma ( 32341527) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866) Leukocyte telomere length ( 32109421 31171785) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte count ( 32888494) Myeloproliferative neoplasms ( 33057200) Nevus count or cutaneous melanoma ( 32341527 30429480) Nonunion in individuals with fractures ( 30680360) Prostate cancer ( 29892016) Red blood cell count ( 29403010) Refractive error ( 32231278) Renal cell carcinoma ( 28598434) Response to metformin in type 2 diabetes (glycemic) ( 21186350) Rheumatoid arthritis ( 30423114 24390342) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396)	Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		98 interacting genes: AATF ABL1 ACTL6B AP1B1 AP2B1 AP3B1 AP3B2 ATR BCAS3 BCL10 BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 COPS5 CREB1 CRX CSNK1D CXXC5 DAXX DCAF1 DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 ERRFI1 ESRRG EXO1 FANCD2 FECH FOXO3 H2AX HIF1A HSPA8 IL24 KAT5 KAT8 LIG4 MAP1S MCM2 MCPH1 MDC1 MDM2 MDM4 MRE11 MT-ND4 MTA3 NBN NR4A1 NREP NSD3 OSGIN1 PARP1 PEX5 POLR2A PPP2R5C PRKDC PTCH1 RAD17 RAD51 RAD9A RANBP9 RASSF1 RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TFF1 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 TRIM29 UCHL3 WRN XPA XRCC5 ZEB1 ZNF821	174 interacting genes: ABL1 APP ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 CALCOCO2 CASP8 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD FHL2 FYN GART GSK3B GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NTRK1 NTRK2 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK2 RNF114 RNF31 RPL3 RPS2 RPS20 RPS27A SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK26 STRADB STUB1 SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZFAND5 ZMYND11 ZNF675 ZRANB1
Entrez ID		472	7189
HPRD ID		06347	03833
Ensembl ID		ENSG00000149311	ENSG00000175104
Uniprot IDs		A0A024R3C7 Q13315	Q9Y4K3
PDB IDs		5NP0 5NP1 6HKA 6K9K 6K9L	1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?
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