IK and MBD3

Data Source:
BioGRID (two hybrid)

		IK	MBD3
Description		IK cytokine	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole	Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Mitotic Spindle Assembly Checkpoint Viral Process Protein Localization To Kinetochore	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation-dependent Heterochromatin Assembly Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		26 interacting genes: APP CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 PFN2 QARS1 RACK1 RBM10 SMU1 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10	76 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA BCL11B CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MBD3L2 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SMARCA4 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655
Entrez ID		3550	53615
HPRD ID		02771	04653
Ensembl ID		ENSG00000113141	ENSG00000071655
Uniprot IDs		Q13123 Q95HA6 Q9UK43	O95983
PDB IDs		5O9Z 6Q8I	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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