MBD3 and MEIS3

Data Source:
BioGRID (two hybrid)

		MBD3	MEIS3
Description		methyl-CpG binding domain protein 3	Meis homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex	Chromatin Nucleus
	Molecular Function	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation-dependent Heterochromatin Assembly Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator	Eye Development Regulation Of Transcription By RNA Polymerase II Brain Development Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS
Interacting Genes		76 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA BCL11B CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MBD3L2 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SMARCA4 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655	22 interacting genes: ATXN1L CCDC116 ENKD1 FAM110A FAM110B FAM161B FAM90A1 HGS HOXA13 INTS4 LENG1 LMO3 MBD3 PIP4K2A PRPF31 PSORS1C2 SUOX TCL1B TLE5 TSGA10IP VEZF1 ZNF417
Entrez ID		53615	56917
HPRD ID		04653	14386
Ensembl ID		ENSG00000071655	ENSG00000105419
Uniprot IDs		O95983	A0A024R0S2 A0A024R0W2 H0YNA8 Q49A38 Q99687
PDB IDs		2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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