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MBD3 and IGFBP6
Data Source:
BioGRID
(two hybrid)
MBD3
IGFBP6
Description
methyl-CpG binding domain protein 3
insulin like growth factor binding protein 6
Image
GO Annotations
Cellular Component
Chromatin
Heterochromatin
Nucleoplasm
Cytoplasm
NuRD Complex
Protein-containing Complex
Extracellular Region
Extracellular Space
Golgi Apparatus
Insulin-like Growth Factor Binary Complex
Molecular Function
DNA Binding
Protein Binding
Methyl-CpG Binding
Nucleosomal DNA Binding
Fibronectin Binding
Signaling Receptor Binding
Protein Binding
Insulin-like Growth Factor I Binding
Insulin-like Growth Factor II Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
DNA Methylation-dependent Heterochromatin Assembly
Brain Development
Heart Development
Aging
Tissue Development
Histone Acetylation
Response To Nutrient Levels
Response To Estradiol
ATP-dependent Chromatin Remodeling
Regulation Of DNA Methylation
Embryonic Organ Development
Regulation Of Signal Transduction By P53 Class Mediator
Activation Of MAPK Activity
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Cell Migration
Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Interacting Genes
76 interacting genes:
AGR2
ANKRD33
ASCL4
ATF7
AURKA
BCL11B
CCDC183
CCHCR1
CCNC
CENPP
CEP70
CEP76
CT55
ERCC6
EXOC4
FAM136A
GADD45GIP1
GATAD2A
GATAD2B
GOLGA2
GOLGA6L9
H3-4
HDAC1
ICA1
IGFBP6
IK
JUN
KDM1A
KDM5B
KRT15
KRT16
LDOC1
LMO3
MAGEA2
MAGEA2B
MBD2
MBD3L1
MBD3L2
MECOM
MEIS3
MEOX1
MEOX2
MIPOL1
MKRN3
MTA2
MTUS2
MYOG
NUTM1
PBX4
PDGFA
PFDN6
PICK1
PKNOX2
PRKAR1B
RAB3IP
RBBP4
RBBP7
RCN3
REL
RINT1
SDCBP
SERTAD3
SMARCA4
SPEN
STMN2
SYCE1
TBC1D19
TET1
TIMM10B
TNNI1
TRIM54
TTC23
USP11
ZBTB7A
ZNF277
ZNF655
37 interacting genes:
ALPP
ANKRD11
AQP1
C1orf74
CCDC116
CCDC28A
CDIPT
CREB5
EFEMP1
EFEMP2
ENKD1
EPDR1
GAS8
GET3
IGF1
IGF2
KRTAP10-8
KRTAP5-7
KRTAP5-9
MBD3
MEIS2
MSGN1
NCALD
PLEKHA7
POU4F2
RABGGTB
RANBP10
SDCBP
SGTA
SMCP
TF
UBAC1
UBQLN1
UBQLN2
UBQLN4
ZNF417
ZNF587
Entrez ID
53615
3489
HPRD ID
04653
00902
Ensembl ID
ENSG00000071655
ENSG00000167779
Uniprot IDs
O95983
P24592
PDB IDs
2MB7
6CC8
6CCG
6CEU
6CEV
1RMJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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