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MBD3 and KRT16
Data Source:
BioGRID
(two hybrid)
MBD3
KRT16
Description
methyl-CpG binding domain protein 3
keratin 16
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Heterochromatin
Nucleoplasm
Cytoplasm
NuRD Complex
Protein-containing Complex
Nucleus
Cytosol
Cytoskeleton
Intermediate Filament
Extracellular Exosome
Molecular Function
DNA Binding
Protein Binding
Methyl-CpG Binding
Nucleosomal DNA Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
DNA Methylation-dependent Heterochromatin Assembly
Brain Development
Heart Development
Aging
Tissue Development
Histone Acetylation
Response To Nutrient Levels
Response To Estradiol
ATP-dependent Chromatin Remodeling
Regulation Of DNA Methylation
Embryonic Organ Development
Regulation Of Signal Transduction By P53 Class Mediator
Morphogenesis Of An Epithelium
Inflammatory Response
Cytoskeleton Organization
Aging
Keratinocyte Differentiation
Negative Regulation Of Cell Migration
Keratinization
Hair Cycle
Innate Immune Response
Intermediate Filament Cytoskeleton Organization
Keratinocyte Migration
Establishment Of Skin Barrier
Cornification
Pathways
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Keratinization
Formation of the cornified envelope
Drugs
Zinc
Zinc acetate
Diseases
Non-epidermolytic palmoplantar keratoderma (NEPPK)
Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Interacting Genes
76 interacting genes:
AGR2
ANKRD33
ASCL4
ATF7
AURKA
BCL11B
CCDC183
CCHCR1
CCNC
CENPP
CEP70
CEP76
CT55
ERCC6
EXOC4
FAM136A
GADD45GIP1
GATAD2A
GATAD2B
GOLGA2
GOLGA6L9
H3-4
HDAC1
ICA1
IGFBP6
IK
JUN
KDM1A
KDM5B
KRT15
KRT16
LDOC1
LMO3
MAGEA2
MAGEA2B
MBD2
MBD3L1
MBD3L2
MECOM
MEIS3
MEOX1
MEOX2
MIPOL1
MKRN3
MTA2
MTUS2
MYOG
NUTM1
PBX4
PDGFA
PFDN6
PICK1
PKNOX2
PRKAR1B
RAB3IP
RBBP4
RBBP7
RCN3
REL
RINT1
SDCBP
SERTAD3
SMARCA4
SPEN
STMN2
SYCE1
TBC1D19
TET1
TIMM10B
TNNI1
TRIM54
TTC23
USP11
ZBTB7A
ZNF277
ZNF655
56 interacting genes:
AMOT
ARFIP2
C1orf109
C1orf216
CARD9
CCDC146
CCDC17
CCHCR1
CCNC
CDK18
CYTH4
EPM2AIP1
GAS8
GNG10
HGS
KIFC3
KLC4
KRT1
KRT2
KRT3
KRT4
KRT5
KRT6A
KRT6C
KRT71
KRT72
KRT73
KRT74
KRT76
KRT78
KRT79
KRT8
KRT80
KRT81
KRT83
KRT85
KRT86
LMO1
LNX1
MBD3
PKN1
POLL
PPP1R18
PRKAA2
PRPH
PUS10
SEMA4C
SGF29
SMARCD1
SMARCE1
SNAPIN
TCHP
TSG101
TTC23
TXLNB
USHBP1
Entrez ID
53615
3868
HPRD ID
04653
01018
Ensembl ID
ENSG00000071655
ENSG00000186832
Uniprot IDs
O95983
P08779
PDB IDs
2MB7
6CC8
6CCG
6CEU
6CEV
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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