IK and PFN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IK	PFN2
Description		IK cytokine	profilin 2
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GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Mitotic Spindle Assembly Checkpoint Viral Process Protein Localization To Kinetochore	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS		Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Fish- and plant-related diet ( 32066663)
Interacting Genes		26 interacting genes: APP CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 PFN2 QARS1 RACK1 RBM10 SMU1 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		3550	5217
HPRD ID		02771	01451
Ensembl ID		ENSG00000113141	ENSG00000070087
Uniprot IDs		Q13123 Q95HA6 Q9UK43	P35080
PDB IDs		5O9Z 6Q8I	1D1J
Enriched GO Terms of Interacting Partners?
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